Which practice helps ensure transparency in clinical trial reporting?

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Multiple Choice

Which practice helps ensure transparency in clinical trial reporting?

Explanation:
Transparency in clinical trial reporting is best achieved when a trial is registered in a public registry before enrolling participants and when the final report follows standardized guidelines such as CONSORT. Registering the trial creates a publicly accessible record of the planned methods, prespecified outcomes, and analysis plans, which helps prevent selective reporting and outcome switching. Following CONSORT ensures the report includes essential details about how participants were randomized, how many were enrolled and analyzed, the exact outcomes measured, results for all prespecified outcomes, and information about adverse events. This combination promotes reproducibility, accountability, and the ability for clinicians and researchers to judge validity and applicability. In contrast, selective reporting, publishing only after sponsor approval, or keeping results inaccessible undermine transparency and bias the evidence base.

Transparency in clinical trial reporting is best achieved when a trial is registered in a public registry before enrolling participants and when the final report follows standardized guidelines such as CONSORT. Registering the trial creates a publicly accessible record of the planned methods, prespecified outcomes, and analysis plans, which helps prevent selective reporting and outcome switching. Following CONSORT ensures the report includes essential details about how participants were randomized, how many were enrolled and analyzed, the exact outcomes measured, results for all prespecified outcomes, and information about adverse events. This combination promotes reproducibility, accountability, and the ability for clinicians and researchers to judge validity and applicability. In contrast, selective reporting, publishing only after sponsor approval, or keeping results inaccessible undermine transparency and bias the evidence base.